Mammalian piRNAs
نویسندگان
چکیده
منابع مشابه
piRNAs
What is their conservation status? Although mass-strandings of beaked whales provide a dramatic example of the vulnerability of these species to human activities, sonar exposure is not the only, nor necessarily the most important conservation threat to these large predators. Beaked whales live in areas that are hard to survey and their diving behavior precludes reliable visual counts, leading t...
متن کاملpiRNAs meet mitochondria.
zuc/MitoPLD encodes a conserved enzyme that localizes to mitochondria and hydrolyzes the mitochondria-specific lipid cardiolipin. Surprisingly, zuc/MitoPLD activity is required for Piwi-interacting RNA (piRNA)-mediated silencing of transposable elements in fly and mouse germlines, suggesting that signaling from mitochondria influences the piRNA pathway.
متن کاملSmall RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.
Small RNAs constitute a large family of regulatory molecules with diverse functions in eukaryotes. Hallmarks of small RNAs are their dependence on double-stranded RNAs (dsRNA)-specific RNase III-type enzymes for biogenesis and their association with Argonaute family proteins for the silencing process. At least two classes of small RNAs have previously been described: microRNAs (miRNAs) derived ...
متن کاملPiwi proteins and piRNAs in mammalian oocytes and early embryos: From sample to sequence
The role of the Piwi/piRNA pathway during mammalian oogenesis has remained enigmatic thus far, especially since experiments with Piwi knockout mice did not reveal any phenotypic defects in female individuals. This is in striking contrast with results obtained from other species including flies and zebrafish. In mouse oocytes, however, only low levels of piRNAs are found and they are not require...
متن کاملA k-mer scheme to predict piRNAs and characterize locust piRNAs
MOTIVATION Identifying piwi-interacting RNAs (piRNAs) of non-model organisms is a difficult and unsolved problem because piRNAs lack conservative secondary structure motifs and sequence homology in different species. RESULTS In this article, a k-mer scheme is proposed to identify piRNA sequences, relying on the training sets from non-piRNA and piRNA sequences of five model species sequenced: ...
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ژورنال
عنوان ژورنال: Spermatogenesis
سال: 2014
ISSN: 2156-5562
DOI: 10.4161/spmg.27889